TreeMicInterV1, Main, Exploration, bibRecord, 000107

Landscape of the genome and host cell response of Mycobacterium shigaense reveals pathogenic features.

Identifieur interne : 000107 ( Main/Exploration ); précédent : 000106; suivant : 000108

Landscape of the genome and host cell response of Mycobacterium shigaense reveals pathogenic features.

Source :

Emerging microbes & infections [ 2222-1751 ] ; 2018.

RBID : pubmed:29934568

Descripteurs français

KwdFr :
- Analyse de profil d'expression de gènes (MeSH), Annotation de séquence moléculaire (MeSH), Antibactériens (pharmacologie), Biologie informatique (méthodes), Facteurs de virulence (génétique), Génome bactérien (MeSH), Génomique (méthodes), Humains (MeSH), Infections à Mycobacterium (génétique), Infections à Mycobacterium (microbiologie), Interactions hôte-pathogène (génétique), Macrophages (microbiologie), Macrophages (métabolisme), Mycobacterium (classification), Mycobacterium (effets des médicaments et des substances chimiques), Mycobacterium (génétique), Mycobacterium (pathogénicité), Phylogenèse (MeSH), Régulation de l'expression des gènes (MeSH), Régulation de l'expression des gènes bactériens (MeSH), Résistance bactérienne aux médicaments (MeSH), Transduction du signal (MeSH), Viabilité microbienne (MeSH), Virulence (MeSH).
MESH :
- effets des médicaments et des substances chimiques : Mycobacterium.
- génétique : Facteurs de virulence, Infections à Mycobacterium, Interactions hôte-pathogène, Mycobacterium.
- microbiologie : Infections à Mycobacterium, Macrophages.
- métabolisme : Macrophages.
- méthodes : Biologie informatique, Génomique.
- pathogénicité : Mycobacterium.
- pharmacologie : Antibactériens.
- Analyse de profil d'expression de gènes, Annotation de séquence moléculaire, Génome bactérien, Humains, Phylogenèse, Régulation de l'expression des gènes, Régulation de l'expression des gènes bactériens, Résistance bactérienne aux médicaments, Transduction du signal, Viabilité microbienne, Virulence.

English descriptors

KwdEn :
- Anti-Bacterial Agents (pharmacology), Computational Biology (methods), Drug Resistance, Bacterial (MeSH), Gene Expression Profiling (MeSH), Gene Expression Regulation (MeSH), Gene Expression Regulation, Bacterial (MeSH), Genome, Bacterial (MeSH), Genomics (methods), Host-Pathogen Interactions (genetics), Humans (MeSH), Macrophages (metabolism), Macrophages (microbiology), Microbial Viability (MeSH), Molecular Sequence Annotation (MeSH), Mycobacterium (classification), Mycobacterium (drug effects), Mycobacterium (genetics), Mycobacterium (pathogenicity), Mycobacterium Infections (genetics), Mycobacterium Infections (microbiology), Phylogeny (MeSH), Signal Transduction (MeSH), Virulence (MeSH), Virulence Factors (genetics).
MESH :
- chemical , genetics : Virulence Factors.
- chemical , pharmacology : Anti-Bacterial Agents.
- classification : Mycobacterium.
- drug effects : Mycobacterium.
- genetics : Host-Pathogen Interactions, Mycobacterium, Mycobacterium Infections.
- metabolism : Macrophages.
- methods : Computational Biology, Genomics.
- microbiology : Macrophages, Mycobacterium Infections.
- pathogenicity : Mycobacterium.
- Drug Resistance, Bacterial, Gene Expression Profiling, Gene Expression Regulation, Gene Expression Regulation, Bacterial, Genome, Bacterial, Humans, Microbial Viability, Molecular Sequence Annotation, Phylogeny, Signal Transduction, Virulence.

Abstract

A systems approach was used to explore the genome and transcriptome of Mycobacterium shigaense, a new opportunistic pathogen isolated from a patient with a skin infection, and the host response transcriptome was assessed using a macrophage infection model. The M. shigaense genome comprises 5,207,883 bp, with 67.2% G+C content and 5098 predicted coding genes. Evolutionarily, the bacterium belongs to a cluster in the phylogenetic tree along with three target opportunistic pathogenic strains, namely, M. avium, M. triplex and M. simiae. Potential virulence genes are indeed expressed by M. shigaense under culture conditions. Phenotypically, M. shigaense had similar infection and replication capacities in a macrophage model as the opportunistic species compared to M. tuberculosis. M. shigaense activated NF-κB, TNF, cytokines and chemokines in the host innate immune-related signaling pathways and elicited an early response shared with pathogenic bacilli except M. tuberculosis. M. shigaense upregulated specific host response genes such as TLR7, CCL4 and CXCL5. We performed an integrated and comparative analysis of M. shigaense. Multigroup comparison indicated certain differences with typical pathogenic bacilli in terms of gene features and the macrophage response.

DOI: 10.1038/s41426-018-0116-z
PubMed: 29934568
PubMed Central: PMC6015043

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000103
to stream Main, to step Curation: 000103

Le document en format XML

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<author><name sortKey="Vissa, Varalakshmi" sort="Vissa, Varalakshmi" uniqKey="Vissa V" first="Varalakshmi" last="Vissa">Varalakshmi Vissa</name>
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<author><name sortKey="Wu, Aiping" sort="Wu, Aiping" uniqKey="Wu A" first="Aiping" last="Wu">Aiping Wu</name>
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<author><name sortKey="Wang, Hongsheng" sort="Wang, Hongsheng" uniqKey="Wang H" first="Hongsheng" last="Wang">Hongsheng Wang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Landscape of the genome and host cell response of Mycobacterium shigaense reveals pathogenic features.</title>
<author><name sortKey="Jiang, Haiqin" sort="Jiang, Haiqin" uniqKey="Jiang H" first="Haiqin" last="Jiang">Haiqin Jiang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042</wicri:regionArea>
<wicri:noRegion>210042</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042</wicri:regionArea>
<wicri:noRegion>210042</wicri:noRegion>
</affiliation>
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<author><name sortKey="Sun, Jiya" sort="Sun, Jiya" uniqKey="Sun J" first="Jiya" last="Sun">Jiya Sun</name>
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<author><name sortKey="Chen, Yanqing" sort="Chen, Yanqing" uniqKey="Chen Y" first="Yanqing" last="Chen">Yanqing Chen</name>
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<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</nlm:affiliation>
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<author><name sortKey="Chen, Zhiming" sort="Chen, Zhiming" uniqKey="Chen Z" first="Zhiming" last="Chen">Zhiming Chen</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042</wicri:regionArea>
<wicri:noRegion>210042</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Wang, Le" sort="Wang, Le" uniqKey="Wang L" first="Le" last="Wang">Le Wang</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Gao, Wei" sort="Gao, Wei" uniqKey="Gao W" first="Wei" last="Gao">Wei Gao</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042</wicri:regionArea>
<wicri:noRegion>210042</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042</wicri:regionArea>
<wicri:noRegion>210042</wicri:noRegion>
</affiliation>
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<author><name sortKey="Shi, Ying" sort="Shi, Ying" uniqKey="Shi Y" first="Ying" last="Shi">Ying Shi</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042</wicri:regionArea>
<wicri:noRegion>210042</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042</wicri:regionArea>
<wicri:noRegion>210042</wicri:noRegion>
</affiliation>
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<author><name sortKey="Zhang, Wenyue" sort="Zhang, Wenyue" uniqKey="Zhang W" first="Wenyue" last="Zhang">Wenyue Zhang</name>
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<author><name sortKey="Mei, Youming" sort="Mei, Youming" uniqKey="Mei Y" first="Youming" last="Mei">Youming Mei</name>
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<author><name sortKey="Vissa, Varalakshmi" sort="Vissa, Varalakshmi" uniqKey="Vissa V" first="Varalakshmi" last="Vissa">Varalakshmi Vissa</name>
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<author><name sortKey="Jiang, Taijiao" sort="Jiang, Taijiao" uniqKey="Jiang T" first="Taijiao" last="Jiang">Taijiao Jiang</name>
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<author><name sortKey="Wu, Aiping" sort="Wu, Aiping" uniqKey="Wu A" first="Aiping" last="Wu">Aiping Wu</name>
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<author><name sortKey="Wang, Hongsheng" sort="Wang, Hongsheng" uniqKey="Wang H" first="Hongsheng" last="Wang">Hongsheng Wang</name>
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<wicri:noRegion>210042</wicri:noRegion>
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<series><title level="j">Emerging microbes & infections</title>
<idno type="eISSN">2222-1751</idno>
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<term>Computational Biology (methods)</term>
<term>Drug Resistance, Bacterial (MeSH)</term>
<term>Gene Expression Profiling (MeSH)</term>
<term>Gene Expression Regulation (MeSH)</term>
<term>Gene Expression Regulation, Bacterial (MeSH)</term>
<term>Genome, Bacterial (MeSH)</term>
<term>Genomics (methods)</term>
<term>Host-Pathogen Interactions (genetics)</term>
<term>Humans (MeSH)</term>
<term>Macrophages (metabolism)</term>
<term>Macrophages (microbiology)</term>
<term>Microbial Viability (MeSH)</term>
<term>Molecular Sequence Annotation (MeSH)</term>
<term>Mycobacterium (classification)</term>
<term>Mycobacterium (drug effects)</term>
<term>Mycobacterium (genetics)</term>
<term>Mycobacterium (pathogenicity)</term>
<term>Mycobacterium Infections (genetics)</term>
<term>Mycobacterium Infections (microbiology)</term>
<term>Phylogeny (MeSH)</term>
<term>Signal Transduction (MeSH)</term>
<term>Virulence (MeSH)</term>
<term>Virulence Factors (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes (MeSH)</term>
<term>Annotation de séquence moléculaire (MeSH)</term>
<term>Antibactériens (pharmacologie)</term>
<term>Biologie informatique (méthodes)</term>
<term>Facteurs de virulence (génétique)</term>
<term>Génome bactérien (MeSH)</term>
<term>Génomique (méthodes)</term>
<term>Humains (MeSH)</term>
<term>Infections à Mycobacterium (génétique)</term>
<term>Infections à Mycobacterium (microbiologie)</term>
<term>Interactions hôte-pathogène (génétique)</term>
<term>Macrophages (microbiologie)</term>
<term>Macrophages (métabolisme)</term>
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<term>Mycobacterium (effets des médicaments et des substances chimiques)</term>
<term>Mycobacterium (génétique)</term>
<term>Mycobacterium (pathogénicité)</term>
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<term>Régulation de l'expression des gènes (MeSH)</term>
<term>Régulation de l'expression des gènes bactériens (MeSH)</term>
<term>Résistance bactérienne aux médicaments (MeSH)</term>
<term>Transduction du signal (MeSH)</term>
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<term>Gene Expression Regulation</term>
<term>Gene Expression Regulation, Bacterial</term>
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<term>Humains</term>
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<front><div type="abstract" xml:lang="en">A systems approach was used to explore the genome and transcriptome of Mycobacterium shigaense, a new opportunistic pathogen isolated from a patient with a skin infection, and the host response transcriptome was assessed using a macrophage infection model. The M. shigaense genome comprises 5,207,883 bp, with 67.2% G+C content and 5098 predicted coding genes. Evolutionarily, the bacterium belongs to a cluster in the phylogenetic tree along with three target opportunistic pathogenic strains, namely, M. avium, M. triplex and M. simiae. Potential virulence genes are indeed expressed by M. shigaense under culture conditions. Phenotypically, M. shigaense had similar infection and replication capacities in a macrophage model as the opportunistic species compared to M. tuberculosis. M. shigaense activated NF-κB, TNF, cytokines and chemokines in the host innate immune-related signaling pathways and elicited an early response shared with pathogenic bacilli except M. tuberculosis. M. shigaense upregulated specific host response genes such as TLR7, CCL4 and CXCL5. We performed an integrated and comparative analysis of M. shigaense. Multigroup comparison indicated certain differences with typical pathogenic bacilli in terms of gene features and the macrophage response.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29934568</PMID>
<DateCompleted><Year>2018</Year>
<Month>10</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>14</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>7</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>Jun</Month>
<Day>22</Day>
</PubDate>
</JournalIssue>
<Title>Emerging microbes & infections</Title>
<ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation>
</Journal>
<ArticleTitle>Landscape of the genome and host cell response of Mycobacterium shigaense reveals pathogenic features.</ArticleTitle>
<Pagination><MedlinePgn>112</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41426-018-0116-z</ELocationID>
<Abstract><AbstractText>A systems approach was used to explore the genome and transcriptome of Mycobacterium shigaense, a new opportunistic pathogen isolated from a patient with a skin infection, and the host response transcriptome was assessed using a macrophage infection model. The M. shigaense genome comprises 5,207,883 bp, with 67.2% G+C content and 5098 predicted coding genes. Evolutionarily, the bacterium belongs to a cluster in the phylogenetic tree along with three target opportunistic pathogenic strains, namely, M. avium, M. triplex and M. simiae. Potential virulence genes are indeed expressed by M. shigaense under culture conditions. Phenotypically, M. shigaense had similar infection and replication capacities in a macrophage model as the opportunistic species compared to M. tuberculosis. M. shigaense activated NF-κB, TNF, cytokines and chemokines in the host innate immune-related signaling pathways and elicited an early response shared with pathogenic bacilli except M. tuberculosis. M. shigaense upregulated specific host response genes such as TLR7, CCL4 and CXCL5. We performed an integrated and comparative analysis of M. shigaense. Multigroup comparison indicated certain differences with typical pathogenic bacilli in terms of gene features and the macrophage response.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Haiqin</ForeName>
<Initials>H</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4924-0465</Identifier>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Jiya</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Suzhou Institute of Systems Medicine, Center of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, 215021, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yanqing</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Zhiming</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Le</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Ying</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Wenyue</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mei</LastName>
<ForeName>Youming</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chokkakula</LastName>
<ForeName>Santosh</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vissa</LastName>
<ForeName>Varalakshmi</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Taijiao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Suzhou Institute of Systems Medicine, Center of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, 215021, China. taijiao@ibms.pumc.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Aiping</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Suzhou Institute of Systems Medicine, Center of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, 215021, China. wap@ism.cams.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Hongsheng</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China. wanghs@ncstdlc.org.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China. wanghs@ncstdlc.org.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>81371751</GrantID>
<Agency>National Natural Science Foundation of China (National Science Foundation of China)</Agency>
<Country></Country>
</Grant>
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</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>06</Month>
<Day>22</Day>
</ArticleDate>
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<MedlineTA>Emerg Microbes Infect</MedlineTA>
<NlmUniqueID>101594885</NlmUniqueID>
<ISSNLinking>2222-1751</ISSNLinking>
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<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
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	Serveur d'exploration sur les interactions arbre microorganisme
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Serveur d'exploration sur les interactions arbre microorganisme

Landscape of the genome and host cell response of Mycobacterium shigaense reveals pathogenic features.

Landscape of the genome and host cell response of Mycobacterium shigaense reveals pathogenic features.

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